Daniel Herschlag
Herschlag studies mechanisms of biological catalysis by RNA and proteins, with the general goal of understanding how RNA and protein enzymes achieve their enormous rate enhancements and exquisite specificity. Mechanistic approaches are also being exploited to understand more complex biological processes, such as translation initiation, RNA chaperones, and the cellular behavior of RNA. Additional areas of investigation include catalysis of phosphoryl transfer by RNA and protein enzymes, model studies of phosphoryl transfer and hydrogen bond energetics, and RNA folding
Last modified Wed, 25 Jul, 2012 at 17:25
| Title | Author(s) | Journal | Date |
|---|---|---|---|
| Challenges in enzyme mechanism and energetics | Kraut DA; Carroll KS; Herschlag D | Annu Rev Biochem | 01-2003 |
| Precision and functional specificity in mRNA decay | Wang Y; Liu CL; Storey JD; Tibshirani RJ; Herschlag D; Brown PO | Proc Natl Acad Sci U S A | 01-2002 |
| Environmental effects on phosphoryl group bonding probed by vibrational spectroscopy: implications for understanding phosphoryl transfer and enzymatic catalysis | Cheng H; Nikolic-Hughes I; Wang JH; Deng H; O'Brien PJ; Wu L; Zhang ZY; Herschlag D; Callender R | J Am Chem Soc | 01-2002 |
| Defining the catalytic metal ion interactions in the Tetrahymena ribozyme reaction | Shan S; Kravchuk AV; Piccirilli JA; Herschlag D | Biochemistry | 01-2001 |
| A single-molecule study of RNA catalysis and folding | Zhuang X; Bartley LE; Babcock HP; Russell R; Ha T; Herschlag D; Chu S | Science | 01-2000 |
