Professor Horowitz initially focused on designing high-performance digital systems by combining work in computer-aided design tools, circuit design, and system architecture. During this time, he built a number of early RISC microprocessors, and contributed to the design of early distributed shared memory multiprocessors. In 1990, Dr. Horowitz took leave from Stanford to help start Rambus Inc., a company designing high-bandwidth memory interface technology. After returning in 1991, he research group pioneered many innovations in high-speed link design, and many of today’s high speed link designs are designed by his former students or colleagues from Rambus.
In the 2000s he started a long collaboration with Prof Levoy on computation photography, that included work that led to the Lytro camera. Dr. Horowitz's current research interests are quite broad and span using EE and CS analysis methods to problems in neuro and molecular biology to creating new agile design methodologies for analog and digital VLSI circuits. He remains interested in learning new things, and building interdisciplinary teams.